Thicker wires in a cable reduce resistance. The resistance of 16-gauge or heavier speaker connection cable has no detectable effect in runs of 50 feet (15 meters) or less in standard domestic loudspeaker connections. Insulation thickness or type also no audible effect as long as the insulation is of good quality and does not chemically react with the wire itself (poor-quality insulation has occasionally been found to accelerate oxidation of the copper conductor, increasing resistance over time). High-power in-car audio systems using 2-ohm speaker circuits require relatively thick cables.
The gauge numbers in SWG (standard wire gauge) and AWG (American wire gauge) reduce as the wire gets larger. Sizing in square millimeters is also common.